Dow Jones industrial futures are down 65 points to 12,549. The broader S&P 500 futures are down 7 points to 1,305. The Nasdaq composite is 14 points lower at 2,443.
The leaders gathering in Brussels hope to focus on how to stimulate economic growth when huge government spending cuts threaten to push many countries back into recession.
The latest data showed Spain's economy shrank in the last three months of 2011.
European markets also declined. In Asia, most indexes fell as investors reacted to Friday's release of data showing the U.S. economy grew more slowly than expected in the fourth quarter.
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